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Discoveries

See the impact of SIRIUS firsthand! This archive showcases exciting discoveries and major breakthroughs made by research groups worldwide. Explore how the power of SIRIUS is elevating small molecule data analysis across diverse fields, including drug discovery, human health, diagnostics, food industry, monitoring, microbiomics, environmental toxicology, archeology, and materials science. For an extensive list of publications by independent research groups using the SIRIUS software framework, click here.

Ketamine’s potential for treating neurological diseases such as depression, PTSD, and chronic pain has sparked significant interest within the medical and scientific communities. (Photo by Robina Weermeijer on Unsplash.)
Discoveries

Ketamine distribution in the brain: understanding drug metabolism with SIRIUS

Ketamine is known for its dual role as an anesthetic and an emerging antidepressant. Despite its long-standing clinical use, the metabolic pathways and pharmacokinetics of ketamine remain poorly understood. A study of ketamine metabolism in the pig brain using SIRIUS provides valuable insights into the distribution of ketamine and its metabolites in different areas of the brain.

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Franziska Hufsky 2024-04-18 No Comments
Discoveries

Quality control using SIRIUS: nutrient profiles of Spirulina and co

Microalgae, such as Spirulina, are promising sources of sustainable nutrition with rich nutrient profiles. Ensuring consistent quality of microalgae as dietary supplements requires a quality control method reporting about their chemical composition. Mass spectrometry-based metabolomics coupled with SIRIUS helps identifying primary and secondary metabolites with potential health benefits, including free fatty acids, polar lipids, and pigments.

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Franziska Hufsky 2024-03-25 No Comments
Discoveries

Hydrate your skin with “biotics”: Understanding the impact of pre/postbiotics on skin health

Our skin, beyond being a physical barrier, hosts a diverse community of microorganisms known as the skin microbiota. “Biotics” have gained attention for their potential to enhance the skin’s health, though their exact mode of action is still unclear. MS-based metabolomics has emerged as a powerful tool to characterize the chemical composition of the skin surface and correlate it with microbial communities. Using CSI:FingerID, researchers identified changes in the skin metabolome that are more pronounced than changes in the microbial composition, suggesting that even subtle shifts in microbial abundance can lead to significant effects on the skin.

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Franziska Hufsky 2023-09-22 1 Comment