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Discoveries

See the impact of SIRIUS firsthand! This archive showcases exciting discoveries and major breakthroughs made by research groups worldwide. Explore how the power of SIRIUS is elevating small molecule data analysis across diverse fields, including drug discovery, human health, diagnostics, food industry, monitoring, microbiomics, environmental toxicology, archeology, and materials science. For an extensive list of publications by independent research groups using the SIRIUS software framework, click here.
Discoveries

Solving the Wolf’s Bane Puzzle: Breaking the Synthesis Bottleneck for Diterpenoid Alkaloid Therapeutics

Diterpenoid alkaloids represent an exceptionally complex class of plant metabolites, highly valued for their therapeutic properties. But their extreme structural complexity makes chemical synthesis practically unfeasible, while their trace abundance in wild plants creates a massive bottleneck for pharmaceutical scale-up. Bio-manufacturing in heterologous hosts offers a viable alternative. But how do these plants assemble the highly complex, medicinal alkaloids and what is the exact origin of their nitrogen building blocks?

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Franziska Hufsky 2026-07-07 No Comments