SIRIUS is setting new standards in molecular identification, enabling the elucidation of previously uncharted compounds, and making a valuable contribution to both science and industry. Here you’ll find a variety of posts showcasing how SIRIUS advances metabolomics and molecular identification.

Discoveries

Explore how research groups are leveraging the power of SIRIUS to elevate their metabolomics data analysis across various fields.

Research Projects

Our commitment is to continue improving SIRIUS and shaping the future of metabolomics research by initiating new research projects.

Press Releases

Read official announcements and statements from Bright Giant, covering partnerships and company milestones.

SIRIUS Background

Learn more about the science and concepts behind SIRIUS to get a deeper understanding of its capabilities.

Application Notes

Learn practical strategies from our real-world applications alongside detailed information on how to get the most out of SIRIUS in your analyses.

Tutorials

Read our step-by-step guides to help you master SIRIUS features and workflows.

Collaborations

Collaborations with leading research groups and industry partners to integrate the latest scientific advancements into SIRIUS for your analyses.

Discoveries: Explore how research groups are leveraging the power of SIRIUS to elevate their metabolomics data analysis across various fields, including drug discovery, diagnostics, food industry, environmental toxicology, and materials science. For an extensive list of discoveries, click here.
Tutorials: Read our step-by-step guides to help you master SIRIUS features and workflows.
Application Notes: Learn practical strategies from our real-world applications alongside detailed information on how to get the most out of SIRIUS in your analyses.
Research Projects: Our commitment is to continue improving SIRIUS and shaping the future of metabolomics research by initiating new research projects.
Background: Learn more about the science and concepts behind SIRIUS to get a deeper understanding of its capabilities.
Press Releases: Read official announcements and statements from Bright Giant, covering partnerships and company milestones.
Collaborations: The SIRIUS team partners with leading research groups and industry partners to integrate the latest scientific advancements, ensuring SIRIUS remains the most versatile and powerful tool for your analyses.

Discoveries

Potential risk of impurities in pesticides: Elucidating structurally related impurities using SIRIUS

Thiacloprid is a first-generation, widely used, neonicotinoid insecticide. Its persistence in the environment and potential adverse effects on human health have raised significant concerns. Elucidating the impurity profile of pesticides is crucial for assessing their environmental impact and potential risks, and setting acceptable limits for impurities. Using enhanced molecular formula identification with SIRIUS, researchers demonstrate an approach for identifying structurally related impurities in pesticides.

Franziska Hufsky 2023-09-11 No Comments

Discoveries

The sky is burning: Elucidating brown carbon composition using SIRIUS

Brown carbon, arising from the combustion of organic matter, exerts a significant influence on atmospheric radiation and global climate. To fully comprehend its impact on atmospheric processes, a thorough characterization of the light-absorbing brown carbon molecules is imperative. Using SIRIUS, researchers have successfully annotated 100 brown carbon chromophores, 33 of which have never been reported before. Through the identification and characterization of these chromophores in diverse atmospheric samples, we gain invaluable insights into their origins, behavior, and the profound implications they have on radiative forcing, cloud formation, and the intricate web of global climate change.

Franziska Hufsky 2023-07-05 No Comments

Discoveries

Green silver: Unveiling the role of biomolecules in plant-based nanoparticle synthesis with SIRIUS

Metal nanoparticles from gold, silver, iron, copper, and others, range in size from 1 to 100 nanometers and have a broad variety of applications in computing, optics, cosmetics, food industry, medicine, and water treatment. Silver nanoparticles, known for their antimicrobial properties, are effective for remediating contaminated waters. Plant extracts are used as reducing agents for the environmentally friendly synthesis of silver nanoparticles. To improve this synthesis, identifying the biomolecules involved in the process is crucial. UHPLC-QTOF-MS and SIRIUS identified the key phenolic compounds involved in the silver reduction.

Franziska Hufsky 2023-06-28 No Comments

Discoveries

Befriend your competitor: SIRIUS identifies metabolite linked to dual-species biofilm pathogenesis in cystic fibrosis

In the world of microbiology, there’s an ongoing battle between different bacterial species competing for survival and dominance. However, under certain conditions, two species can actually thrive together in a dual-species biofilm. The cooperation between P. aeruginosa and S. aureus in cystic fibrosis leads to increased disease severity. But so far, only little is known about the chemical communication mechanisms between those bacteria. SIRIUS identifies a metabolite that could be related to the increased pathogenesis of this dual-species biofilm in cystic fibrosis.

Franziska Hufsky 2023-06-14 No Comments

Discoveries

It’s in your breath: pediatric asthma diagnosis using SIRIUS compound annotation

Pediatric asthma poses diagnostic challenges due to its variable presentation. Breath analysis could be a game-changer in pediatric allergic asthma management. By identifying unique exhaled metabolic signatures using SESI-MS and SIRIUS, this cutting-edge approach distinguishes children with allergic asthma from healthy controls, aiding accurate diagnosis and personalized treatment.

Franziska Hufsky 2023-05-26 No Comments

Discoveries

Long-term storage in biobanks: Identifying unstable metabolites with SIRIUS

Neonatal dried blood spots are not only important for newborn screening but also a powerful source for investigating the potential metabolic etiologies of various diseases using untargeted LC-MS-based metabolomics. So far it is unclear whether the metabolites in those samples remain stable in storage. SIRIUS helps to investigate the stability of metabolites and classes of molecules.

Franziska Hufsky 2023-05-11 No Comments

Discoveries

A liverwort under stress: compound classification with SIRIUS to detect metabolic shifts

Liverworts are chemically diverse plants with unique cell organelles responsible for the synthesis and storage of specialized metabolites. Untargeted metabolomics was used to analyze the metabolic stress response of liverworts without isolating individual metabolites. SIRIUS classified the affected compounds, and helped to map the biochemical pathways of the unique stress response of liverworts compared to vascular plants.

Franziska Hufsky 2023-03-31 No Comments

Discoveries

Scouring the oceans: Revealing the chemical potential of marine microorganisms with SIRIUS

Marine microorganisms offer a rich source of bioactive compounds with unique structures and remarkable biological activity. This makes them an important resource for the search for new therapeutic compounds, which is one of the most pressing challenges of our time. To narrow down the search to the most promising microorganisms, SIRIUS is nearly doubling the number of natural products annotated to estimate the chemical potential of microbial extracts.

Franziska Hufsky 2023-03-23 No Comments