
Solving the Wolf’s Bane Puzzle: Breaking the Synthesis Bottleneck for Diterpenoid Alkaloid Therapeutics
Diterpenoid alkaloids represent an exceptionally complex class of plant metabolites, highly valued for their therapeutic properties. But their extreme structural complexity makes chemical synthesis practically unfeasible, while their trace abundance in wild plants creates a massive bottleneck for pharmaceutical scale-up. Bio-manufacturing in heterologous hosts offers a viable alternative. But how do these plants assemble the highly complex, medicinal alkaloids and what is the exact origin of their nitrogen building blocks?




