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Discover how research groups are leveraging the power of SIRIUS to elevate their metabolomics data analysis across various fields, including drug discovery, diagnostics, food industry, environmental toxicology, and materials science. Explore exciting discoveries and find out how our tools can empower you to uncover the next groundbreaking molecule. For an extensive list of discoveries, click here.

SIRIUS is setting new standards in molecular identification, enabling the elucidation of previously uncharted compounds, and making a valuable contribution to both science and industry. Our commitment is to continue improving SIRIUS and shaping the future of metabolomics research by initiating new research projects to further this mission.
Discoveries

Green silver: Unveiling the role of biomolecules in plant-based nanoparticle synthesis with SIRIUS

Metal nanoparticles from gold, silver, iron, copper, and others, range in size from 1 to 100 nanometers and have a broad variety of applications in computing, optics, cosmetics, food industry, medicine, and water treatment. Silver nanoparticles, known for their antimicrobial properties, are effective for remediating contaminated waters. Plant extracts are used as reducing agents for the environmentally friendly synthesis of silver nanoparticles. To improve this synthesis, identifying the biomolecules involved in the process is crucial. UHPLC-QTOF-MS and SIRIUS identified the key phenolic compounds involved in the silver reduction.

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Franziska Hufsky 2023-06-28 No Comments
Discoveries

Befriend your competitor: CSI:FingerID identifies metabolite linked to dual-species biofilm pathogenesis in cystic fibrosis

In the world of microbiology, there’s an ongoing battle between different bacterial species competing for survival and dominance. However, under certain conditions, two species can actually thrive together in a dual-species biofilm. The cooperation between P. aeruginosa and S. aureus in cystic fibrosis leads to increased disease severity. But so far, only little is known about the chemical communication mechanisms between those bacteria. CSI:FingerID identifies a metabolite that could be related to the increased pathogenesis of this dual-species biofilm in cystic fibrosis.

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Franziska Hufsky 2023-06-14 No Comments
Discoveries

It’s in your breath: pediatric asthma diagnosis using CSI:FingerID compound annotation

Pediatric asthma poses diagnostic challenges due to its variable presentation. Breath analysis could be a game-changer in pediatric allergic asthma management. By identifying unique exhaled metabolic signatures using SESI-MS and CSI:FingerID, this cutting-edge approach distinguishes children with allergic asthma from healthy controls, aiding accurate diagnosis and personalized treatment.

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Franziska Hufsky 2023-05-26 No Comments
Newborn baby feet
Discoveries

Long-term storage in biobanks: Identifying unstable metabolites with CSI:FingerID and CANOPUS

Neonatal dried blood spots are not only important for newborn screening but also a powerful source for investigating the potential metabolic etiologies of various diseases using untargeted LC-MS-based metabolomics. So far it is unclear whether the metabolites in those samples remain stable in storage. CSI:FingerID and CANOPUS help to investigate the stability of metabolites and classes of molecules.

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Franziska Hufsky 2023-05-11 No Comments
Radula complanata
Discoveries

A liverwort under stress: compound classification with CANOPUS to detect metabolic shifts

Liverworts are chemically diverse plants with unique cell organelles responsible for the synthesis and storage of specialized metabolites. Untargeted metabolomics was used to analyze the metabolic stress response of liverworts without isolating individual metabolites. CANOPUS classified the affected compounds, and helped to map the biochemical pathways of the unique stress response of liverworts compared to vascular plants.

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Franziska Hufsky 2023-03-31 No Comments
Discoveries

Scouring the oceans: Revealing the chemical potential of marine microorganisms with SIRIUS

Marine microorganisms offer a rich source of bioactive compounds with unique structures and remarkable biological activity. This makes them an important resource for the search for new therapeutic compounds, which is one of the most pressing challenges of our time. To narrow down the search to the most promising microorganisms, SIRIUS is nearly doubling the number of natural products annotated to estimate the chemical potential of microbial extracts.

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Franziska Hufsky 2023-03-23 No Comments
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