18 novel hop-acid analogues identified in brewery waste revealing its high antioxidant potential.
32-44% of polar chemicals in offshore oil discharges are persistent, in particular N-substituted aromatic ring structures.
33 emerging contaminants identified in global tap water — 25 for the first time.
37 unique secondary metabolites identified in the metabolome of the invasive Guinea grass.
48 antioxidation active metabolites identified in Ginger.
155 new brown carbon chromophores identified in aqueous-phase reactions of α-dicarbonyls with ammonium or amines.
Accelerated photoaging and contact with water significantly increase the degradation and transformation rates of rubber-derived chemicals.
Annotating nitazine (high-potency synthetic opioid) metabolites and major markers for enhanced detection.
Annotation of 80% of the previously unknown metabolite features of tall wheatgrass root exudates.
Anti-viral compounds in Caesalpinia mimosoides help to inhibit influenza by targeting two critical viral proteins.
Antioxidant-rich extract from Ceratonia siliqua pods with potential for a biocompatible topical therapy.
Arctic microbes eat fresh plants instead of old soil—keeping ancient carbon safely stored.
Ash trees resistant to ash dieback could also help protect against emerald ash borer infestations.
Biochemical pathways and compounds of the unique stress response of liverworts with potential cytotoxicity against human cancer cell lines.
Biopesticide 6-PP is produced via the polyketide biosynthesis pathway in Trichoderma fungi.
Biotransformation of levofloxacin in wastewater by basidiomycete fungal strains leads to decreased antibiotic activity.
Blechnic acid B: novel lignan discovered in ferns of the Blechnaceae family.
Brazilian iron-cave bacteria produce rare cyclopeptides with significant cytotoxic activity against cancer cells.
Cell surface glycans and membrane lipids are influential drivers of adaptation to heat stress in rice coral hosting thermosensitive and thermotolerant symbionts.
Chemical composition and anti-inflammatory properties of prickly goldenfleece could be a valuable source of bioactive compounds for food and health applications.
Chemical pollination syndrome: bird-syndrome nectar shows convergence on chemical traits distinct from bee-syndrome nectar.
Climate and island residence time influence plant specialised chemical diversity.
Common and previously unreported parabens and plastic-related contaminants identified in human milk.
Cortisol, sumatriptan, and glutamine are crucial metabolites associated with the treatment of migraines with triptans.
Decoding the crucial role of the gut microbiome in altering the chemical structure and efficacy of GPCR drugs.
Decreased concentration of two carotenoids after UV filter explosion might be indicative of an alteration in the photosynthetic capacity of corals.
Deep-sea black yeasts adapt to extreme salinity by remodeling membranes and accumulating plant-like amino acids and novel aminocyclitols to maintain osmotic balance.
Defense syndromes in willows result from a complex interplay of selection pressures and trade-offs.
Detailing the metabolic basis for the production of sesquiterpenoids in the medicinal mushroom Sanghuangporus.
Different paths to chemical diversity in highland and lowland willow species.
Diurnal carbohydrate and metabolite production in sugarcane and energy-cane reveals differences in growth strategies.
Domesticated common bean varieties exhibit reduced metabolic diversity and specialization compared to their wild counterparts.
Drug metabolites and drugrelated impurities in human plasma identified without reference standards and a priori knowledge of first- and second-pass drug metabolism.
DX protein enhances expression of specialized metabolic pathways in the Streptomyces genomes and might lead to the discovery of novel bioactive molecules.
Eccrine finger sweat analysis reveals healthy lifestyle shifts in children with overweight after long-term nutritional education and lifestyle intervention.
Endophytic bacteria aid in controlling fusarium wilt disease and enhancing tomato plant growth through bioactive secondary metabolites.
Environmental fate of formulation ingredients in commercial pesticides.
Ethanol extraction for human faecal metabolomics is a valid, safer, and more economical alternative to the common methanol extraction.
Extremophilic fungi dissolve Martian-like hematite using a cocktail of siderophores and organic acids, creating stable chemical biosignatures detectable by future planetary missions.
False daisies contain anti-inflammatory, antioxidant and anti-collagenase ingredients with anti-aging potential .
Females of the red-necked wasp moth have higher concentrations of potential defensive compounds than males.
FODMAPs are influencing health-positive metabolites in plasma of irritable bowel syndrome patients.
Glacial rivers deliver highly bioavailable aliphatic matter to Arctic fjords, which is rapidly transformed or diluted as it enters the marine carbon cycle.
Grapevine root extracts rich in oligostilbenes show high antifungal activity against fungal plant pathogen that affects cereal crops.
Green solvents can effectively extract diverse bioactive compounds from lemon balm leaves.
Highly halogenated compounds are potential contributors to the high antibacterial activity in tetrasporophyte stage of red alga Asparagopsis armata.
Highly specific "Gold" markers in 14 yellow dye plants enable the precise botanical authentication of ancient textiles.
Homologous series of previously overlooked polymerization byproducts detected near fluoropolymer production plant.
Honey ia a bio-indicator for flame retardants in air.
Hybrid diversity in Baccharis is driven by secondary metabolites, while primary metabolism remains conserved.
Identification of 100 light-absorbing brown carbon molecules, 33 of which have never been reported before.
Identification of fenozan in wastewater as a key biomarker for human exposure to synthetic phenolic antioxidants.
Identify and link microbial metabolites to their producers with microbeMASST and SIRIUS.
Increase in released greenhouse gases in Northern peatlands is likely due to changes in metabolic activity rather than microbial community changes.
Innovative approach to prioritise chemical profiling over exhaustive identification for analysing and comparing biomes.
In ruminants, rutin is first degraded to quercetin by rumen microbes, which is then biotransformed into various phenolic compounds that ultimately result in 4-methylcatechol-1-sulfate and isorhamnetin-glucuronide sulfate as the main metabolites found in the blood
Interplay between dietary patterns, plasma metabolites, and colorectal cancer risk
Kakadu plum extracts shows antiproliferative effects against MCF7 breast adenocarcinoma cells.
Ketamine distribution in the brain improves understanding on how ketamine traverses the blood-brain barrier.
Key chemical cues for designing a biomaterial that mimics the chemical landscape of healthy reefs to enhance coral settlement.
Link between microbial community structure and chemical profile of the surface metabolome in Saccharina latissima.
Lipophilic diterpenoids and retinoids in seaweed reduce rumen methane production by 30% while shifting fermentation patterns.
Major antihypertensive constituents of Kinkéliba decoction confirmed through high-resolution metabolite annotation.
Marine prokaryotes hold vast potential for discovering new drug candidates.
Matrix Method: Streamlined, automated method using barcoded tubes to extract both DNA and metabolites simultaneously from human and environmental samples.
MCheM chemical labeling provides structural information to constrain the molecular structure search space in SIRIUS and boost annotation accuracy.
Metabolic adaptations of a salt-tolerant willow are specific to the plant organ and the salt anion.
Metabolite from actinobacteria strain from Egyptian soil is a promising candidate as a multidrug efflux pump inhibitor.
Metabolite linked to dual-species biofilm pathogenesis in cystic fibrosis identified.
Metabolites altered up to 14 years before diagnosis enable the prediction of Crohn’s disease with high accuracy years before symptoms appear.
Metabolites from citrus juices improve herbal therapy against paracetamol-induced liver toxicity.
Metabolites identified from A. absinthium extracts support the traditional use for stomach problems.
Metabolites in maize grown on sustainable push-pull fields that enhance its natural defense against pests.
Metabolites of Aspergillus niveus are promising leads for developing new potent cholinesterase inhibitors against Alzheimer's disease.
Metabolome composition of mature and immature seeds from different cereal and leguminous plants.
Metabolomic profiles of three Ficus species to investigate phytochemistry, chemotaxonomy and potential medical use.
Metabolomics study of black apples revealed the chemical diversity of fungus-produced secondary metabolites in black apple microbiomes.
Method to reveal the chemical potential of marine microorganisms based on microbial extracts.
Microbial biocontrol agents lead to major metabolic re-programming in fungi
Microbial decomposition of human cadavers as data basis for a forensic tool to predict time since death.
Microbiome of eelgrass produces broad-spectrum antibiotics with potent activity against waterborne pathogens.
Microtiter plate cultivation systems provide a robust platform for discovering novel bacterial natural products by enabling broader access to chemical diversity.
Molecular explanation for the longer time needed to establish the low-compatibility interaction between the ectomycorrhizal fungus Tricholoma vaccinum and pine.
Monophasic extraction with 400 nm beads and 60-minute on-bead protein digestion is the most reproducible, efficient, and cost-effective solution for in-house multiomics (metabolites, lipids, proteins) workflows in HepG2 cells.
Multi-omic analysis reveals PHACTR1 as a master regulator of cell cycle, iron metabolism, and mitochondrial bioenergetics in human vascular cells.
Multi-omics reveals coating-specific signatures—like ceramides and glucosinolates—that govern biofilm resilience.
Multidimensional optimization of cell morphology increases the reproducibility of microbial metabolic footprints by 50% across different cultivation systems.
Mycobacteria use the MelH protein to neutralize toxic lipids, allowing them to survive in the host.
Mycobacteria use the MelH protein to neutralize toxic lipids, allowing them to survive in the host.
Neuroprotective effects of secondary metabolites in mulberry plant extracts on Alzheimer’s Disease.
New chlorophylls in coastal halophyte plant that exhibit potent, selective toxicity against colorectal cancer cells.
New degradation metabolites and potential metabolic pathway of novel designer drug O-PCE identified.
New ecdysteroids with potential skin aging therapeutic benefits discovered in the Korean plant Ajuga spectabilis.
New protocol to identify structurally related impurities in pesticides for assessing their environmental impact and risks.
Nitrogen source drives Microcystis (a primary driver of harmful freshwater algal blooms) exometabolome composition more than strain, with nitrate fueling peak chemical diversity.
Non-targeted approach uncovers plastic-related contaminants in liquor products, including three unanticipated compounds.
Novel method to study ozonation in water treatment plants to remove cyanobacterial toxins from drinking water.
Novel urinary biomarkers to distinguish giant panda pregnancy from pseudopregnancy as early as the first weeks of embryonic development.
Nutritional components of coconut flesh.
Oscillibacter species in the gut microbiome may help lower cholesterol levels, potentially benefiting heart health.
Plant extracts as reducing agents for the environmentally friendly synthesis of silver nanoparticles.
Plants tailor their defenses based on the presence of herbivores rather than herbivore identity.
Potent antidiabetic compounds in cluster fig (Ficus racemosa) fruit extracts.
Potentially allergenic transformation products of tattoo pigments identified in new online-LC-EC-MS approach.
Potential new UV-protective amino acids identified in Baltic flatfish eyes.
Potential to enhance the skin health: changes in the skin metabolome more pronounced than in microbial composition.
Previously overlooked toxic drivers identified in the air, including 2-indanone and 2-vinylpyridine.
Previously undetected chemicals with potential estrogenic activity in drinking water from regions with high breast cancer incidence.
Robust biomarker candidate identified for standardizing exhaled breath sample collection.
Rust infection in common beans enriched metabolomic pathways, biosynthesis of secondary metabolites, protein processing in the endoplasmic reticulum, and purine metabolism among others.
Selective cytotoxic activity of dinoflagellate Amphidinium eilatiense extracts against cancer cells is linked to a rich chemical diversity.
Significant differences in metabolite abundance and composition among microalgae Spirulina, Chlorella, and Amphora.
SIRIUS as part of a new screening platform to efficiently discover antifungal drugs from natural sources.
SIRIUS compound classification reveals how maternal and environmental factors shape infant gut metabolism.
SIRIUS tentatively identified dadahol A in hemp roots, guiding the discovery of neolignans with cytotoxic activity against pediatric cancer cells.
Specific metabolites identified as potential selection traits to improve Fusarium resistance in maize.
Stable isotope labeling serves as a detection strategy to distinguish biologically relevant features from background signals.
Strong interdependence and metabolic rewiring of the algal partner in radiolaria photosymbiosis, where the host extensively transforms algal metabolites and the algal cell membrane is significantly rearranged.
Terpenoids might contribute to the success of M. calvescens as an invasive species.
Testing different reversed-phase LC columns and mobile phase modifiers to improve coverage of intestinal lipids for non-targeted lipidomics.
The antimicrobial agent trimethoprim influences chemical interactions between cystic fibrosis pathogens affecting virulence factors.
The International Space Station has a unique and extreme microbial and chemical environment with distinct signatures within each module.
The methanogenic archaeon Methanosarcina barkeri can reduce naturally occurring iron oxides in aquatic sediments' methanogenic zones.
The microbial diversity and metabolite production of the tropical ascidian Eudistoma vannamei reveals its role as a holobiont rich in secondary metabolites.
Tracing thousands of neuroactive metabolites from plant to pill: Vertigoheel retains characteristic constituents from its natural sources in all tested formulations.
Understanding the dynamics of thawing permafrost and its impact on climate change is essential for developing strategies to cope with its effects.
Unique phytochemical fingerprints of Phragmites australis lineages suggest that metabolomic evenness may be a critical trait within plant species.
Unstable metabolites in neonatal dried blood spot should be carefully monitored in long-term storage.
Untargeted 2D chromtography MS/MS approach unravels the complex structures of depolymerized lignin to turn it into valuable biomaterials.
Upcycling by-products: Coffee waste is a rich source of hydrophilic antioxidants and lipophilic sterols.
White adipose tissue plays a crucial role in regulating metabolism throughout the hibernation cycle.
Women with ovarian malignancies had significantly higher urinary levels of endocrine-disrupting chemicals.
Zinc anodes, used to protect against corrosion in marine environments, affect the metabolism of oysters.